منابع مشابه
Gamete Fusion: Key Protein Identified
Is there a common mechanism of eukaryotic sex? Two recent reports highlight an ancient and widely distributed protein that is key to gamete fusion and is a potential target for malaria vaccines.
متن کاملMolecular dissection of IZUMO1, a sperm protein essential for sperm-egg fusion.
Although the membrane fusion of spermatozoon and egg cells is the central event of fertilization, the underlying molecular mechanism remains virtually unknown. Gene disruption studies have showed that IZUMO1 on spermatozoon and CD9 on oocyte are essential transmembrane proteins in sperm-egg fusion. In this study, we dissected IZUMO1 protein to determine the domains that were required for the fu...
متن کاملEndoplasmic reticulum protein 29 (ERp29), a protein related to sperm maturation is involved in sperm-oocyte fusion in mouse
BACKGROUND Sperm-oocyte fusion is a critical step in fertilization, which requires a series of proteins from both spermatozoa and oocyte to mediate membrane adhesion and subsequent fusion. A rat spermatozoa membrane protein is endoplasmic reticulum protein 29 (ERp29), which significantly increases on the sperm surface as well as in the cytoplasm of epididymal epithelia from caput to cauda as th...
متن کاملSensor Fusion in Identified Visual Interneurons
Animal locomotion often depends upon stabilization reflexes that use sensory feedback to maintain trajectories and orientation. Such stabilizing reflexes are critically important for the blowfly, whose aerodynamic instability permits outstanding maneuverability but increases the demands placed on flight control. Flies use several sensory systems to drive reflex responses, and recent studies hav...
متن کاملIdentification and purification of a sperm surface protein with a potential role in sperm-egg membrane fusion
Sperm-egg plasma membrane fusion during fertilization was studied using guinea pig gametes and mAbs to sperm surface antigens. The mAb, PH-30, strongly inhibited sperm-egg fusion in a concentration-dependent fashion. When zona-free eggs were inseminated with acrosome-reacted sperm preincubated in saturating (140 micrograms/ml) PH-30 mAb, the percent of eggs showing fusion was reduced 75%. The a...
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ژورنال
عنوان ژورنال: Genome Biology
سال: 2005
ISSN: 1465-6906
DOI: 10.1186/gb-spotlight-20050314-01